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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPH1 All Species: 36.97
Human Site: T414 Identified Species: 62.56
UniProt: P17752 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17752 NP_004170.1 444 50985 T414 S I Q I L K D T K S I T S A M
Chimpanzee Pan troglodytes XP_001172877 875 97166 T414 S I Q I L K D T K S I T S A M
Rhesus Macaque Macaca mulatta Q2HZ26 490 56076 T460 S I E I L K D T R S I E N V V
Dog Lupus familis XP_854768 828 92147 T455 S I Q I L K D T K S I T S A M
Cat Felis silvestris
Mouse Mus musculus P17532 447 51325 T417 S V Q V L R D T K S I T S A M
Rat Rattus norvegicus P09810 444 51050 S414 S I Q V L R D S K S I T S A M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519524 444 50785 T414 S V Q L L K D T K G I A C V V
Chicken Gallus gallus P70080 445 51121 T415 S V Q I L K D T K S I A S V V
Frog Xenopus laevis Q92142 481 55388 T451 S V D I L K D T K S I A M V V
Zebra Danio Brachydanio rerio NP_840091 471 53899 Y440 K R P F S V R Y N P Y T Q S V
Tiger Blowfish Takifugu rubipres NP_001027848 479 54964 T449 S V D V L K D T S S I N S V V
Fruit Fly Dros. melanogaster P17276 452 51642 V422 A Y T Q S V E V L D S K P Q I
Honey Bee Apis mellifera XP_394674 508 57954 A454 S V E V L T D A Q K I T A V V
Nematode Worm Caenorhab. elegans P90925 457 52111 V427 R V E I L D K V A A L Q R L A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 50.5 64.6 52.5 N.A. 89.4 91.2 N.A. 85.3 85.8 75.2 72.8 71.6 51.1 57.2 48.3 N.A.
Protein Similarity: 100 50.6 79.3 53.1 N.A. 95.3 96.1 N.A. 93.6 95.5 87.3 83.6 84.1 71.4 71.6 68 N.A.
P-Site Identity: 100 100 60 100 N.A. 80 80 N.A. 53.3 73.3 60 6.6 53.3 0 33.3 13.3 N.A.
P-Site Similarity: 100 100 86.6 100 N.A. 100 100 N.A. 73.3 86.6 73.3 20 73.3 20 73.3 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 8 8 8 0 22 8 36 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 15 0 0 8 79 0 0 8 0 0 0 0 0 % D
% Glu: 0 0 22 0 0 0 8 0 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 36 0 50 0 0 0 0 0 0 79 0 0 0 8 % I
% Lys: 8 0 0 0 0 58 8 0 58 8 0 8 0 0 0 % K
% Leu: 0 0 0 8 86 0 0 0 8 0 8 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 36 % M
% Asn: 0 0 0 0 0 0 0 0 8 0 0 8 8 0 0 % N
% Pro: 0 0 8 0 0 0 0 0 0 8 0 0 8 0 0 % P
% Gln: 0 0 50 8 0 0 0 0 8 0 0 8 8 8 0 % Q
% Arg: 8 8 0 0 0 15 8 0 8 0 0 0 8 0 0 % R
% Ser: 79 0 0 0 15 0 0 8 8 65 8 0 50 8 0 % S
% Thr: 0 0 8 0 0 8 0 65 0 0 0 50 0 0 0 % T
% Val: 0 50 0 29 0 15 0 15 0 0 0 0 0 43 50 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 8 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _